What is dietary supplement NMN

To put it bluntly, it is the abbreviation of β-nicotinamide mononucleotide, which is the precursor substance used by the human body to synthesize the core coenzyme NAD+. Most of the related products currently circulating on the market are dietary supplements approved overseas. They are neither a miracle elixir of longevity touted by merchants nor a scourge.

The first to emerge was in 2013, when a team from Harvard Medical School published the conclusion of a mouse experiment. After a week of supplementing NMN to old mice equivalent to a 60-year-old human physiological age, their exercise endurance, hair condition, and cell metabolism indicators all returned to levels close to those of young mice. This result was a big hit in both the biotech circle and the consumer market at the time, and related dietary supplement products gradually became popular among ordinary people.

I have been paying attention to this kind of supplements for four or five years. There are many people around me who have tried it, and the difference in feedback is really big: I have a friend who only sleeps an average of 4 hours a day while working on Internet projects all year round. He has been eating legally imported NMN for almost two years. He said that the most intuitive change is that he used to have to be drowsy for two or three days to recover after staying up late at night, but now he gets enough sleep. You can basically recover in six hours, and the indicators such as liver and kidney function and uric acid in the annual physical examination are also within the normal range. There is also a 40-year-old sister who followed the trend and bought an unknown model from an Internet celebrity live broadcast room. After taking it for three months, she did not feel that her energy had improved. A routine physical examination also found that uric acid increased by nearly 50%. After half a month, it fell back to the normal level after a reexamination.

The reason why there is such bipolar feedback is that the current research on NMN has not yet reached a complete conclusion. Most of the current effective effectiveness data comes from animal experiments. Large-scale and long-term clinical experimental data on humans are still very limited. The views of the academic community are not unified: there are small-scale human trial data showing that supplementing appropriate doses of NMN in middle-aged and elderly people is indeed effective. It can improve problems such as decreased energy, poor sleep quality, and reduced muscle endurance caused by aging; many studies have also suggested that people with high uric acid and abnormal liver and kidney function may increase their metabolic burden by supplementing hastily. Some scholars even have doubts about its long-term safety. After all, there is no long-term follow-up data spanning more than ten years, and many potential risks have not been fully understood.

To be honest, there is really no need to deify this thing. You can compare NAD+ to the energy power bank in the cells. The older you are and the more irregular your work and rest are, the faster the capacity of the power bank will drop and the lower the charging efficiency. NMN is essentially one of the raw materials that can help improve the charging efficiency. But if you are only in your early 20s, you usually work regularly and eat a balanced diet, and the NAD+ synthesized by yourself is completely sufficient. Additional supplementation is purely an unnecessary burden on the liver and kidneys. In addition, I would like to mention that our country has not yet approved the production and sale of NMN as ordinary food or health food in the country. The regular products that can be purchased now are overseas compliant products through cross-border e-commerce channels. When buying, be sure to check the regulatory qualifications of the corresponding country, and don’t go with the wechat brand that even confused the ingredient list. I have seen someone in the relevant fan community before eating Sanwu products, and found that alanine aminotransferase spiked within two weeks, and the gain outweighed the loss. If you are really curious and want to try it, it is best to do a full physical examination first to make sure that you do not have problems such as high uric acid or abnormal liver and kidney function. Start taking it with a small dose, and do not take it as a medical treatment. If you feel uncomfortable after taking it, stop it and go to the hospital for examination as soon as possible.